Product Type
Condition
Binding
Collectible Attributes
Free Shipping
Seller Location
Seller Rating
Published by Birkhäuser, 1991
ISBN 10: 0817635661ISBN 13: 9780817635664
Seller: HPB-Red, Dallas, TX, U.S.A.
Book
Hardcover. Condition: Good. Connecting readers with great books since 1972! Used textbooks may not include companion materials such as access codes, etc. May have some wear or writing/highlighting. We ship orders daily and Customer Service is our top priority!.
Published by Taylor & Francis, 1990, 1990
Seller: First Choice Books, Coeurd'Alene, ID, U.S.A.
HB--VG; black glossy cover. contains photos, charts, tables, diagrams; references;
Published by Birkhäuser, 1996
ISBN 10: 0817638792ISBN 13: 9780817638795
Seller: HPB-Red, Dallas, TX, U.S.A.
Book
hardcover. Condition: Good. Connecting readers with great books since 1972! Used textbooks may not include companion materials such as access codes, etc. May have some wear or writing/highlighting. We ship orders daily and Customer Service is our top priority!.
Published by Birkhauser, 1991
ISBN 10: 0817635661ISBN 13: 9780817635664
Seller: K & L KICKIN' BOOKS, Corinth, TX, U.S.A.
Book First Edition
Hardcover. Condition: Very Good. Dust Jacket Condition: No Dj. First Edition. B&R-158Ex-college library with usual library features.
Published by Birkhäuser, 1991
ISBN 10: 0817635661ISBN 13: 9780817635664
Seller: Midtown Scholar Bookstore, Harrisburg, PA, U.S.A.
Book
Hardcover. Condition: Very Good. Very Good - Crisp, clean, unread book with some shelfwear/edgewear, may have a remainder mark - NICE Standard-sized.
Published by Birkhäuser, 2012
ISBN 10: 1461581516ISBN 13: 9781461581512
Seller: Lucky's Textbooks, Dallas, TX, U.S.A.
Book
Condition: New.
Published by Birkhäuser, 2013
ISBN 10: 1489967400ISBN 13: 9781489967404
Seller: Lucky's Textbooks, Dallas, TX, U.S.A.
Book
Condition: New.
Published by Birkhäuser, 2012
ISBN 10: 1461581516ISBN 13: 9781461581512
Seller: GreatBookPrices, Columbia, MD, U.S.A.
Book
Condition: New.
Published by Birkhäuser, 2013
ISBN 10: 1489967400ISBN 13: 9781489967404
Seller: GreatBookPrices, Columbia, MD, U.S.A.
Book
Condition: New.
Published by Birkhäuser, 2012
ISBN 10: 1461581516ISBN 13: 9781461581512
Seller: booksXpress, Bayonne, NJ, U.S.A.
Book Print on Demand
Soft Cover. Condition: new. This item is printed on demand.
Published by Birkhäuser, 2013
ISBN 10: 1489967400ISBN 13: 9781489967404
Seller: booksXpress, Bayonne, NJ, U.S.A.
Book
Soft Cover. Condition: new.
Published by Birkhäuser, 2012
ISBN 10: 1461581516ISBN 13: 9781461581512
Seller: Ria Christie Collections, Uxbridge, United Kingdom
Book Print on Demand
Condition: New. PRINT ON DEMAND Book; New; Fast Shipping from the UK. No. book.
Published by Birkhauser
ISBN 10: 0817635661ISBN 13: 9780817635664
Seller: Romtrade Corp., STERLING HEIGHTS, MI, U.S.A.
Book
Condition: New. Brand New Original US Edition.We Ship to PO BOX Address also. EXPEDITED shipping option also available for faster delivery.This item may ship from the US or other locations in India depending on your location and availability.
Published by Birkhäuser Boston, 2012
ISBN 10: 1461581516ISBN 13: 9781461581512
Seller: Buchpark, Trebbin, Germany
Book
Condition: Sehr gut. Zustand: Sehr gut - Gepflegter, sauberer Zustand. | Seiten: 528 | Sprache: Englisch | Produktart: Bücher.
Published by Birkhäuser, 2012
ISBN 10: 1461581516ISBN 13: 9781461581512
Seller: GreatBookPricesUK, Castle Donington, DERBY, United Kingdom
Book
Condition: New.
Published by Birkhäuser, 2013
ISBN 10: 1489967400ISBN 13: 9781489967404
Seller: GreatBookPricesUK, Castle Donington, DERBY, United Kingdom
Book
Condition: New.
Published by Birkhauser
ISBN 10: 0817635661ISBN 13: 9780817635664
Seller: SMASS Sellers, IRVING, TX, U.S.A.
Book
Condition: New. Brand New Original US Edition. Customer service! Satisfaction Guaranteed. This item may ship from the US or our Overseas warehouse depending on your location and stock availability. We Ship to PO BOX Location also.
Published by Birkhäuser Boston Mai 2012, 2012
ISBN 10: 1461581516ISBN 13: 9781461581512
Seller: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Germany
Book Print on Demand
Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Since the apoE4 allele is a risk factor or susceptibility gene in late-onset familial and sporadic AD, the mechanism of disease expression may involve metabolic effects that are isoform specific. Isoform-specific interactions of apoE therefore become critical in the mechanism of AD pathogenesis. Detailed characterization of the binding of the apoE isoforms with proteins and peptides relevant to the pathology of the disease may be critical in understanding disease pathogenesis. These critical isoform-specific interactions of apoE may involve interactions with proteins and pep tides in the defining neuropathologic lesions of the disease, the neurofibrillary tangle and senile plaque. Other possible critical isoform-specific interactions include the mechanism of internalization, intracellular trafficking, and subsequent metabolism. In addition, differential post-translational modifications of apoE isoforms may determine differences in metabolism contributing to the pathogenesis of the disease. Oxidation of apoE may confer several isoform-specific, biochemically distinct properties. Since {3A peptide binds apoE in the lipoprotein binding domain of the protein and not in the receptor-binding domain, apoE could target bound {3A4 peptide to neurons via the LRP receptor. Internalization of the apoEI {3A peptide complex into the cell, by the same route as the apoE-containing lipoproteins, would result in incorporation into primary lysosomes and pH dependent dissociation. The demonstration of apoE in the cytoplasm of neurons, with isoform-specific interactions of apoE with the microtubule-binding protein tau demonstrated in vitro, suggest additional, testable hypotheses of disease pathogenesis. 528 pp. Englisch.
Published by Birkhäuser, 2012
ISBN 10: 1461581516ISBN 13: 9781461581512
Seller: Revaluation Books, Exeter, United Kingdom
Book
Paperback. Condition: Brand New. reprint edition. 509 pages. 9.00x6.00x1.25 inches. In Stock.
Published by Springer-Verlag New York Inc., 2013
ISBN 10: 1489967400ISBN 13: 9781489967404
Seller: Kennys Bookshop and Art Galleries Ltd., Galway, GY, Ireland
Book
Condition: New. Series: Advances in Alzheimer Disease Therapy. Num Pages: 504 pages, 23 black & white illustrations, biography. BIC Classification: MJND. Category: (P) Professional & Vocational. Dimension: 235 x 155 x 26. Weight in Grams: 771. . 2013. Softcover reprint of the original 1st ed. 1991. Paperback. . . . .
Published by Birkh?user, 2012
ISBN 10: 1461581516ISBN 13: 9781461581512
Seller: Kennys Bookshop and Art Galleries Ltd., Galway, GY, Ireland
Book
Condition: New. 2012. Softcover reprint of the original 1st ed. 1994. paperback. . . . . .
Published by Birkhäuser Boston, 2012
ISBN 10: 1461581516ISBN 13: 9781461581512
Seller: AHA-BUCH GmbH, Einbeck, Germany
Book
Taschenbuch. Condition: Neu. Druck auf Anfrage Neuware - Printed after ordering - Since the apoE4 allele is a risk factor or susceptibility gene in late-onset familial and sporadic AD, the mechanism of disease expression may involve metabolic effects that are isoform specific. Isoform-specific interactions of apoE therefore become critical in the mechanism of AD pathogenesis. Detailed characterization of the binding of the apoE isoforms with proteins and peptides relevant to the pathology of the disease may be critical in understanding disease pathogenesis. These critical isoform-specific interactions of apoE may involve interactions with proteins and pep tides in the defining neuropathologic lesions of the disease, the neurofibrillary tangle and senile plaque. Other possible critical isoform-specific interactions include the mechanism of internalization, intracellular trafficking, and subsequent metabolism. In addition, differential post-translational modifications of apoE isoforms may determine differences in metabolism contributing to the pathogenesis of the disease. Oxidation of apoE may confer several isoform-specific, biochemically distinct properties. Since {3A peptide binds apoE in the lipoprotein binding domain of the protein and not in the receptor-binding domain, apoE could target bound {3A4 peptide to neurons via the LRP receptor. Internalization of the apoEI {3A peptide complex into the cell, by the same route as the apoE-containing lipoproteins, would result in incorporation into primary lysosomes and pH dependent dissociation. The demonstration of apoE in the cytoplasm of neurons, with isoform-specific interactions of apoE with the microtubule-binding protein tau demonstrated in vitro, suggest additional, testable hypotheses of disease pathogenesis.
Published by Birkhäuser Boston, 2012
ISBN 10: 1461581516ISBN 13: 9781461581512
Seller: moluna, Greven, Germany
Book Print on Demand
Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Since the apoE4 allele is a risk factor or susceptibility gene in late-onset familial and sporadic AD, the mechanism of disease expression may involve metabolic effects that are isoform specific. Isoform-specific interactions of apoE therefore become critic.
Published by Birkhäuser Boston, 2013
ISBN 10: 1489967400ISBN 13: 9781489967404
Seller: moluna, Greven, Germany
Book Print on Demand
Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Springer Book Archives.
Published by Birkhäuser, 2012
ISBN 10: 1461581516ISBN 13: 9781461581512
Seller: Kennys Bookstore, Olney, MD, U.S.A.
Book
Condition: New. 2012. Softcover reprint of the original 1st ed. 1994. paperback. . . . . . Books ship from the US and Ireland.
Published by Springer-Verlag New York Inc., 2013
ISBN 10: 1489967400ISBN 13: 9781489967404
Seller: Kennys Bookstore, Olney, MD, U.S.A.
Book
Condition: New. Series: Advances in Alzheimer Disease Therapy. Num Pages: 504 pages, 23 black & white illustrations, biography. BIC Classification: MJND. Category: (P) Professional & Vocational. Dimension: 235 x 155 x 26. Weight in Grams: 771. . 2013. Softcover reprint of the original 1st ed. 1991. Paperback. . . . . Books ship from the US and Ireland.
Published by Birkhauser 2012-05, 2012
ISBN 10: 1461581516ISBN 13: 9781461581512
Seller: Chiron Media, Wallingford, United Kingdom
Book
PF. Condition: New.
Published by Birkhäuser, 1996
ISBN 10: 0817638792ISBN 13: 9780817638795
Seller: Romtrade Corp., STERLING HEIGHTS, MI, U.S.A.
Book
Condition: New. Brand New Original US Edition.We Ship to PO BOX Address also. EXPEDITED shipping option also available for faster delivery.This item may ship from the US or other locations in India depending on your location and availability.
Published by Birkhäuser, 1996
ISBN 10: 0817638792ISBN 13: 9780817638795
Seller: SMASS Sellers, IRVING, TX, U.S.A.
Book
Condition: New. Brand New Original US Edition. Customer service! Satisfaction Guaranteed. This item may ship from the US or our Overseas warehouse depending on your location and stock availability. We Ship to PO BOX Location also.
Published by Birkhäuser, 2013
ISBN 10: 1489967400ISBN 13: 9781489967404
Seller: GreatBookPricesUK, Castle Donington, DERBY, United Kingdom
Book
Condition: As New. Unread book in perfect condition.